Epigenetic mechanisms in the development & human diseases Disease modeling using human ESC/iPSC & reprogramming Regenerative Medicine Molecular/Immuno-pathogenesis of neurodegenerative diseases Autophagy & hypoxia regulation
Biography
Dr. Yu (Aaron) Tang obtained his bachelor degree from Sichuan University in China, and earned his Ph.D. degree from the Institute of Health Sciences, Chinese Academy of Sciences. As a Ph.D. student, his research interests and experiences widely across from delving into the epigenetic mechanisms in the immuno-pathogenesis of Parkinson's disease (PD) to the neural differentiation of pluripotent stem cells (ESCs/iPSCs). Specifically, he worked on (1) the epigenetic regulation/switch of distinct microglia phenotypes (M1 & M2), and its potential effects in the development of PD; and (2) the epigenetic mechanisms underlying the formation of neural progenitor cells (NPCs), and developed highly-efficient methods for NPC generation. Now as a postdoctoral researcher in the UT Southwestern, he focused on the differentiation of human ESCs/iPSCs towards neurons to probe possible molecular mechanisms that were employed for better modeling the features of neurodegenerative diseases including aging status.